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US 4,614,825 AGranted
7-oxabicycloheptane and 7-oxabicycloheptene compounds
AssigneeE. R. Squibb & Sons, Inc.
InventorsDavid L. Snitman, Martin F. Haslanger, Peter W. Sprague
Life of this patent
Estimating the term…
Abstract
7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
Claims12
A compound having the structural formula ##STR54## and including all stereoisomers thereof;
- wherein A and B may be the same or different and A is CH.dbd.CH or (CH.sub.2).sub.2,
- B is CH.dbd.CH, C.tbd.C, or (CH.sub.2).sub.2 ;
- m is 1 to 8;
- X is ##STR55## wherein Z is SO.sub.2 --Q (wherein Q is lower alkyl or aryl), ##STR56## or OR.sup.2 wherein R.sup.2 is H;
- Y is alkyl;
- substituted alkyl;
- aryl-lower alkyl;
- alkenyl;
- alkynyl;
- aryl;
- pyridyl;
- pyridyl-lower alkyl;
- substituted pyridyl;
- thienyl;
- thienylalkyl;
- substituted thienyl;
- cycloalkyl;
- substituted cycloalkyl;
- cycloalkylalkyl or substituted cycloalkylalkyl;
- and represents a single bond or double bond with the proviso that where represents a double bond, A is CH.dbd.CH and B is CH.dbd.CH or (CH.sub.2).sub.2 and Y is other than alkenyl or alkynyl;
- wherein alkyl or lower alkyl by itself or as part of another group contains 1 to 12 carbons and unless otherwise indicated may be unsubstituted or substituted with a halo, CF.sub.3, alkoxy, aryl, alkyl-aryl, haloaryl, cycloalkyl or alkylcycloalkyl substituent;
- the term alkenyl by itself or as part of another group contains 3 to 6 carbons;
- the term alkynyl by itself or as part of another group contains 3 to 6 carbons;
- the term aryl by itself or as part of another group is phenyl or naphthyl unsubstituted or substituted with lower alkyl, halogen or lower alkoxy;
- the term cycloalkyl by itself or as part of another group contains 3 to 12 carbons and may be unsubstituted or substituted with 1 or 2 halogens, 1 or 2 lower alkyls and/or 1 or 2 lower alkoxy groups;
- the term substituted pyridyl refers to a pyridyl group substituted with 1 or 2 halogen or 1 or 2 lower alkyl groups;
- the term substituted thienyl refers to a thienyl group substituted with 1 or 2 halogens or 1 or 2 lower alkyl groups;
- the term (CH.sub.2).sub.m refers to straight or branched chain radicals having from 1 to 8 carbons in the normal chain.
25 more elements
Dependencies are inferred from the claim text.