5H-2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same
AssigneeEgis Gyogyszergyar
InventorsTibor Lang, Jeno Korosi, Ferenc Andrasi, Peter Botka, Tamas Hamori, Pal Berzsenyi, Katalin Goldschmidt, Gabor Zolyomi, Istvan Elekes, Zsuzsanna Lang nee Rihmer
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Abstract
The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. The new 5H-2,3-benzodiazepine derivatives of the invention possess valuable central nervous effect and in particular exert antiaggressive, anxiolytic, narcosis potentiating and soporific properties.
Claims7
A 5H-2,3-Benzodiazepine of the formula I and pharmaceutically acceptable acid addition salts thereof, ##STR3## wherein R and R.sub.1 each represent hydrogen, chlorine, C.sub.1-4 alkyl or C.sub.1-4 alkoxy,
- R.sub.2 stands for hydrogen or C.sub.1-4 alkyl,
- R.sub.3 and R.sub.4 each denote C.sub.1-4 alkyl, or combined they denote methylene.
A compound selected from the group consisting of 1-(4-aminophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine, 1-(3-aminophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine, 1-4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine, 1-(3-methyl-4-aminophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine, 1-(3-chloro-4-aminophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine and pharmaceutically acceptable acid addition salts of these compounds.
Dependencies are inferred from the claim text.