Adminiculum for antitumor agents
AssigneeTsumura Juntendo, Inc.
InventorsMasaki Aburada, Shigefumi Takeda, Eiko Itoh, Moe Matsushita, Eikichi Hosoya
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Abstract
Adminiculum increasing the antitumor activities of mitomycin C and doxorubicin hydrochloride and decreasing the side effects associated with their use comprising an aqueous or aqueous organic solvent extract of a crude preparation of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix, a method for preparing said adminiculum and a method for its use. In addition, compositions and methods for treating tumor-bearing patients are disclosed.
Claims14
A composition for treating tumor-bearing patients consisting essentially of (a) an effective amount of an antitumor agent selected from the group consisting of mitomycin C and doxorubicin hydrochloride and (b) an effective amount of an aqueous or aqueous organic solvent extract of a crude preparation comprising Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix, as active agents.
A composition for use in increasing antitumor activity of mitomycin C and for reducing side effects induced thereby consisting essentially of an effective amount of an aqueous or aqueous solvent extract of a crude preparation comprising Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix, as active agent.
A composition for use in increasing antitumor activity of doxorubicin hydrochloride and for reducing side effects induced thereby consisting essentially of an effective amount of an aqueous or aqueous solvent extract of a crude preparation comprising Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix as active agent.
A method for treating tumor-bearing patients comprising administering a composition consisting essentially of (a) an effective amount of an antitumor agent selected from the group consisting of mitomycin C and doxorubicin hydrochloride and (b) an effective amount of an aqueous or aqueous organic solvent extract of a crude preparation comprising Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix.
A method for increasing the antitumor activity of mitomycin C and for reducing side effects induced thereby comprising administering an effective amount of an aqueous or aqueous organic solvent extract of a crude preparation comprising Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix.
A method for increasing the antitumor activity of doxorubicin hydrochloride and for reducing side effects induced thereby comprising administering an effective amount of an aqueous or aqueous organic solvent extract of a crude preparation comprising Astragli radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix.
Dependencies are inferred from the claim text.