Powdery pharmaceutical composition for nasal administration
AssigneeTeijin Limited
InventorsYoshiki Suzuki, Kunio Sekine, Tsuneji Nagai, Naoki Nambu, Yuji Nishimoto
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Abstract
What is provided by this invention is a powdery pharmaceutical composition for nasal administration comprising physiologically active polypeptide or its derivative such as calcitonin, insulin, etc. and a water-absorbing and water-insoluble base. The pharmaceutical composition allows polypeptide or its derivative to be efficiently absorbed through the nasal macous membrane when it is nasally administered.
Claims18
A method for nasal pharmaceutical administration which comprises the step of contacting the nasal mucosa with an intranasally effective amount of a powdery pharmaceutical composition for nasal adminstration consisting essentially of:
- (A) a physiologically active polypeptide or its derivative selected from the group consisting of a peptide hormone, a physiologically active protein, an enzyme protein and a vaccine, and (B) a water-absorbing and water-insoluble base, wherein at least 90 wt % of the particles of said composition have an effective diameter ranging from 10 to 250 microns.
Dependencies are inferred from the claim text.