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US 4,609,551 AGranted
Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
OwnerArnold Caplan, Glenn T. Syftestadinventors
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OwnerArnold Caplan, Glenn T. Syftestadinventors
Estimating the term…
A process for exposing live cells to a soluble bone protein and transferring the cells into appropriate skeletal sites to initiate or enhance local chondrogenesis or osteogenesis. Isogenic fibroblasts are exposed in vitro to a soluble bone protein capable of stimulating in vitro and/or in vivo a chondrogenic response. The fibroblasts are then transferred in vivo in a manner effective to prevent diffusion away from the implantation site so that the desired chondro/osteogenesis reaction can proceed. Delivery systems include: combining the activated fibroblasts with a biodegradable matrix; suspending the activated fibroblasts in a solution suitable for intra-articular injection; and attaching the fibroblasts to allografts and prosthetic devices.
In a method of stimulating in vivo growth of skeletal tissue the improvement comprising the steps of combining soluble bone protein purified to a state effective to initiate chondrogenesis with fibroblast cells to form a protein-cell combination and placing the protein-cell combination in condition for in vivo administration.
In a method of stimulating in vivo growth of skeletal tissue the improvement comprising the steps of combining soluble bone protein purified to a state effective to initiate chondrogenesis with fibroblast cells to form a protein-cell combination, and further combining the protein-cell combination with a biodegradable carrier to form a composite mass.
In a method of stimulating in vivo growth of skeletal tissue the improvement comprising the steps of combining soluble bone protein purified to a state effective to initiate chondrogenesis with fibroblast cells to form a protein-cell combination, and incubating said protein-cell combination with an allograft.
In a method of stimulating in vivo growth of skeletal tissue the improvement comprising the steps of combining soluble bone protein purified to a state effective to initiate chondrogenesis with fibroblast cells to form a protein-cell combination, and incubating said protein-cell combination with a prosthesis in a solution which promotes cell adhesion to the prosthesis.
A method of stimulating in vivo growth of skeletal tissue at an anatomical site comprising the steps of:
A method of stimulating in vivo growth of skeletal tissue at an anatomical site comprising the steps of:
A method of stimulating in vivo growth of skeletal tissue at an anatomical site comprising the steps of:
A method of stimulating in vivo growth of skeletal tissue at a site of a joint cavity articular comprising the steps of:
Dependencies are inferred from the claim text.