Long-acting composition
AssigneeJapan Chemical Research Co., Ltd.
InventorHajime Hiratani
Life of this patent
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Abstract
A composition wherein a physiologically active polypeptide or a glycoprotein of human origin, for instance, urokinase, kallikrein or leukocyte interferon, is coupled to a polyoxyethylene-polyoxypropylene copolymer. The composition is effective in the human body for a prolonged period of time.
Claims15
A long-acting composition which comprises a physiologically active polypeptide or glycoprotein of human origin coupled to a polyoxyethylene-polyoxypropylene copolymer having a molecular weight between about 1,000 and about 10,000 by means of a coupling agent capable of linking the terminal hydroxyl group of said copolymer with the amino group of said active substance.
A long-acting composition which comprises a physiologically active polypeptide or glycoprotein of human origin selected from the group of human epidermal growth factor, urokinase, kallikrein and leukocyte interferon, coupled to a polyoxyethylene-polyoxypropylene copolymer having a molecular weight between about 1,000 and about 10,000, by means of a coupling agent capable of linking the terminal hydroxyl group of said copolymer with the amino group of said active substance.
Dependencies are inferred from the claim text.