Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties
AssigneeSyntex (U.S.A.) Inc.
InventorsArthur F. Kluge, Anthony L. Willis, Counde O'Yang
Life of this patent
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Abstract
Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis are compounds depicted in formulas (1), (2), and (3): ##STR1## wherein: n is 2 or 3; R.sub.1 is CH.sub.2 OH, CHO, CO.sub.2 R or CO.sub.2 H; R.sub.2 is hydrogen or methyl; and R.sub.3 is linear or branched alkyl having 5-10 carbon atoms, ##STR2## optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 1 or 2; and R is ##STR3## in which each R.sub.4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.
Claims55
A compound of formula (1), (2) or (3) ##STR23## wherein:
- n is 2 or 3;
- R.sub.1 is CH.sub.2 OH, CHO, CO.sub.2 R or CO.sub.2 H;
- R.sub.2 is hydrogen or methyl;
- and
- R.sub.3 is linear or branched alkyl having 5-10 carbon atoms, ##STR24## optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen,
- in which
- a is 0, 1 or 2;
- b is 3-7;
- m is 1 or 2;
- and
- R is ##STR25## in which each R.sub.4 is independently hydrogen or lower alkyl having 1-6 carbon atoms,
- and the pharmaceutically acceptable, non-toxic salts and esters thereof.
Dependencies are inferred from the claim text.