Methods and compositions for plasma and organ imaging
AssigneeWashington Research Foundation
InventorsJames B. Bassingthwaighte, Stephen E. Little, Kenneth A. Krohn
Life of this patent
Estimating the term…
Abstract
Halogenated dibenzazepines, particularly flouro- or iododesmethylimipramine, find use for measuring regional blood flows and for retention in particular organs for radioactive imaging. Such compositions are introduced into the arterial flow leading to the organ, and the compositions bind to the organ as a result of interaction with cellular receptors. The compositions have been found to display very high retention rates in the organ for relatively long periods of time.
Claims9
A method for concentrating a radioactive label in a functioning mammalian organ, which comprises:
- introducing into the arterial flow of said organ a fluid containing a radioactive halogenated desmethylimipramine in an amount sufficient for said radioactive dibenzazepine to become bound to said organ.
A method for imaging a target organ which comprises injecting into the arterial stream of a mammalian host upstream from said organ, a sufficient amount of radioactive fluorine or iodine substituted desmethylimipramine in a physiologically acceptable carrier, whereby said desmethylimipramine becomes concentrated in said target organ;
- and detecting the emissions from said radioactive fluorine or iodine bound to said target organ.
3"-Halodesmethylimipramine, wherein said halo is radioactive fluorine or iodine.
A composition useful for imaging an organ in a mammalian host which comprises radioactive 3"-fluoro- or -iododesmethylimipramine in a physiologically acceptable carrier.
Dependencies are inferred from the claim text.