Sorbitol, process for its preparation, and use thereof
AssigneeMerck Patent GmbH
InventorsFriedrich Reiff, Hartmut Hartner, Arno Basedow, Hans-Wolfgang Hugenbusch, Peter C. Schmidt, Hans Bardonner
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AssigneeMerck Patent GmbH
InventorsFriedrich Reiff, Hartmut Hartner, Arno Basedow, Hans-Wolfgang Hugenbusch, Peter C. Schmidt, Hans Bardonner
Estimating the term…
A modified sorbitol with improved tableting properties, viz, has a melting point of about 96.degree. C., a bulk density of 0.3-0.6 g/ml, a .gamma.-sorbitol content of at least 90%, a purity of at least 98%, a specific surface area of 0.7-1.5 m.sup.2 /g, a bending strength of at least 7 N/mm.sup.2 at a compressive force of at least 10,000 N, and a friability of less than 1% at a compressive force of at least 10,000 N, can be prepared by obtaining a sorbitol solution by hydrogenation of crystallized glucose at a temperature below 170.degree. C., and spray-drying this solution at a temperature of 140.degree. to 170.degree. C. The sorbitol thus obtained has a water content of less than 1%. The sorbitol is useful for the production of compressed formulations.
A process for producing a modified sorbitol-mannitol composition having improved tableting properties, comprising the step of spray drying a concentrated aqueous solution of sorbitol having no more than 2% impurities other than mannitol, and containing up to 15% by weight of mannitol relative to the weight of the sorbitol, at a drying gas temperature of 140.degree.-170.degree. C., under such conditions that the resultant spray dried sorbitol/mannitol composition has a moisture content of less than 1% by weight.
A modified sorbitol/mannitol composition having up to 15% by weight of mannitol with respect to the sorbitol, said composition having improved tableting properties, and wherein said sorbitol has
A process for producing a modified sorbitol/mannitol composition having improved tableting properties, comprising the spray-drying of a concentrated aqueous solution of sorbitol having no more than 2% impurities, at a drying gas temperature of 140.degree.-170.degree. C., and subsequently adding up to 15% by weight mannitol to the composition.
Dependencies are inferred from the claim text.