Packing materials for chromatographic use and a method for analysis of an enantiomer mixture using the same

A method for liquid chromatographic analysis which comprises separating and analyzing an enantiomer mixture of a compound having an --NH-- group, a --CONH-- group, or an --OCO-- group bonded to an asymmetric carbon atom thereof by using a packing material for chromatographic use comprising an inorganic carrier having hydroxyl groups at the surface thereof having grafted thereon an .alpha.-arylalkylamine derivative which is formed by bonding an optically active .alpha.-arylkalkylamine and an aminoalkylsilane through a dibasic carboxylic acid,

• wherein the grafted .alpha.-arylalkylamine derivative is an organosilane represented by general formula (I):
• ##STR10## wherein R.sub.1, R.sub.2 and R.sub.3 each, which may be the same or different, is an alkyl group, an alkoxyl group, a hydroxyl group or a halogen atom, with proviso that at least one thereof is an alkoxyl group or a halogen atom;
• R.sub.4 is an alkyl group;
• Ar is a naphthyl group, which may be substituted;
• X is --NHCO-- or --N.sup..sym. H.sub.3.O.sup..crclbar. CO--;
• Y is a lower alkylene group or a phenylene group;
• n is an integer of from 2 to 4;
• and * indicates an asymmetric carbon atom.