Surfactant and pharmaceutical compositions containing same
AssigneeTokyo Tanabe Company Limited
InventorsTsunetomo Takei, Yosaku Kanazawa, Kazuo Masuda, Yuji Tanaka
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Abstract
A surfactant having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. The surfactant consists essentially of, based on the total weight of the surfactant, 50.6-85.0% of a chlorine phosphogylceride, 4.5-37.6% of an acid phospholipid, 4.6-24.6% of a fatty acid or its analogue and 0.1-10.0% of a lipoprotein derived from the lung of a mammal. These components cooperate to form a kind of film at a gas-liquid interface within pulmonary alveoli and reduce the surface tension. A pharmaceutical composition comprising the surfactant is useable for the clinical treatment of respiratory distress syndrome.
Claims26
A surfactant consisting essentially of (1) a choline phosphoglyceride, (2) an acid phospholipid, (3) a fatty acid or its analogue, and (4) a lipoprotein derived from cattle or pig lungs, the lipoprotein being composed of 47.9 to 70.2%(w/w) of phospholipid part, 23.4 to 48.0%(w/w) of protein part, 1.8 to 5.0%(w/w) of water and 1.4 to 2.4%(w/w) of unknown component parts and having a molecular weight of 30,000 to 38,000, characterized in that the content of the choline phosphoglyceride (1) is 50.6 to 85.0%(w/w), the content of the acid phospholipid (2) is 4.5 to 37.6%(w/w), the content of the fatty acid or its analogue (3) is 4.6 to 24.6%(w/w), the content of the lipoprotein (4) is 0.1 to 10.0%(w/w), all based on the total weight of the surfactant, and characterized in that, when the surfactant is added dropwise to the surface of physiological saline at 37.degree. C. in an amount of 0.8 to 1.5 .mu.g per square centimeter of the surface area, the surfactant gives an equilibrium surface tension of 23.9 to 35.0 dynes/cm in a time of 30 to 100 seconds.
Dependencies are inferred from the claim text.