Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsJohn J. Tegeler, Craig J. Diamond, Grover C. Helsley
Life of this patent
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Abstract
There are described compounds of the formula ##STR1## where n is 2 or 3, X and Y are each independently hydrogen, loweralkyl, or halogen, and R.sub.1 and R.sub.2 are each independently hydrogen, loweralkyl, cyano, beta,beta,beta-trichloroethyoxycarbonyl, cyclopropylmethyl, phenethyl, or cyanoethyl, but at least one of the two is loweralkyl, which are useful as antidepressant and analgesic agents; novel intermediate compounds for preparing said compounds; and methods for synthesizing the foregoing compounds.
Claims29
A compound of the formula ##STR22## where n is 2 or 3;
- X and Y are each independently hydrogen, loweralkyl or halogen, R.sub.1 is loweralkyl, and R.sub.2 is hydrogen, loweralkyl, cyano, beta,beta,beta-trichloroethoxyoxycarbonyl, cyclopropylmethyl, phenethyl or cyanoethyl, with the proviso that when n is 2 and both X and Y are hydrogen, R.sub.2 is not hydrogen or loweralkyl, or a pharmaceutically acceptable acid addition salt thereof.
An antidepressant composition comprising an effective depression alleviating amount of a compound of the formula ##STR23## where n is 2 or 3, X and Y are each independently hydrogen, loweralkyl or halogen, R.sub.1 is loweralkyl, and R.sub.2 is hydrogen, loweralkyl, cyano, beta,beta,beta-trichloroethoxycarbonyl, cyclopropylmethyl, phenethyl or cyanoethyl, with the proviso that when n is 2 and both X and Y are hydrogen, R.sub.2 is not hydrogen or loweralkyl, or a pharmaceutically acceptable acid addition salt thereof and a carrier therefor.
An analgesic composition comprising an effective pain alleviating amount of a compound of the formula ##STR24## where n is 2 or 3, X and Y are each independently hydrogen, loweralkyl or halogen, R.sub.1 is loweralkyl, and R.sub.2 is hydrogen, loweralkyl, cyano, beta,beta,beta-trichloroethoxycarbonyl, cyclopropylmethyl, phenethyl or cyanoethyl with the proviso that when n is 2 and both X and Y are hydrogen, R.sub.2 is not hydrogen or loweralkyl, or a pharmaceutically acceptable acid addition salt thereof and a carrier therefor.
Dependencies are inferred from the claim text.