Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
AssigneeThe Trustees of Columbia University in the City of New York
InventorLaszlo Z. Bito
Life of this patent
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Abstract
Ocular hypertension and glaucoma can be effectively controlled in primates through topical application of an effective amount of an eicosanoid or an eicosanoid derivative to the surface of an afflicted eye. Eicosanoids, particularly the prostaglandins PGE.sub.2 and PGF.sub.2.alpha., and derivatives thereof, have been found effective in quantities less than about 1000 .mu.g per eye. Ophthalmic compositions containing C.sub.1 to C.sub.5 alkyl esters of PGF.sub.2.alpha. are presently preferred for use in treating ocular hypertension and glaucoma in primates, including man.
Claims19
A method for treating hypertension or glaucoma in a primate subject's eye comprising periodically contacting the surface of the eye with an amount of an eicosanoid or an eicosanoid derivative effective to reduce intraocular pressure in the eye without any substantial initial increase in said pressure and to maintain reduced intraocular pressure.
A composition for topical treatment of glaucoma in the eye of a primate subject comprising an effective amount of PGF.sub.2.alpha. methyl ester, PGF.sub.2.alpha. ethyl ester, PGF.sub.2.alpha. isopropyl ester, or PGF.sub.2.alpha. isobutyl ester dissolved in an ophthalmically compatible carrier.
A composition for the topical treatment of glaucoma in a primate subject's eye comprising an effective amount of a lower alkyl ester of PGF.sub.2.alpha. dissolved in an ophthalmically compatible carrier.
Dependencies are inferred from the claim text.