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US 4,597,762 AGranted
Collagen preparation
AssigneeHeyl Chemisch-pharmazeutische Fabrik GmbH & Co. KG
InventorsPeter Walter, Michael Walter
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Abstract
A collagen preparation comprising collagen-I for human or veterinary medicine obtainable by proteolyzing, cross-linking, reducing, optionally heat treating, and finally sterilizing mammalian collagen I material under conservation of its biological texture.
Claims21
A collagen preparation comprising collagen-I for human or veterinary therapy obtained by the following consecutive steps:
- (a) proteolyzing mammalian collagen-I material in presence of ficin and L-cysteine in an aqueous medium at a pH value of 5.5-6.5 and at a temperature of 30.degree. to 50.degree. C.,
- (b) cross-linking the material obtained according to step (a) with at least one aliphatic dialdehyde of 2 to 10 carbon atoms,
- (c) reducing the material obtained according to step (b) with a reducing bleaching agent and
- (d) finally sterilizing the material, wherein the texture of the collagen-I material is preserved throughout all steps.
1 more element
A process for preparation of a collagen-I preparation comprising
- (a) proteolyzing mammalian collagen-I material in presence of ficin and L-cysteine in an aqueous medium at a pH value of 5.5-6.5 and at a temperature of 30.degree. to 50.degree. C.,
- (b) cross-linking the material obtained according to step (a) with at least one aliphatic dialdehyde of 2 to 10 carbon atoms,
- (c) reducing the material obtained according to step (b) with a reducing bleaching agent and
- (d) finally sterilizing the material,
- wherein the texture of the collagent-I material is preserved throughout all steps.
2 more elements
Dependencies are inferred from the claim text.