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US 4,596,819 AGranted
Modified tripeptides
AssigneeWarner-Lambert Company
InventorsErnest D. Nicolaides, Francis J. Tinney, James S. Kaltenbronn, Dana E. DeJohn, Elizabeth A. Lunney, W. Howard Roark, Joseph T. Repine
Life of this patent
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Abstract
Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from ##STR1## --CH.sub.2 NH--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --CH.sub.2 SO.sub.2 --, --CH.sub.2 CH.sub.2 -- and --CH.dbd.CH-- are described as well as methods for their manufacture, pharmaceutical compositions and methods for treatment, especially of cognitive disorders, depression, morphine dependency and parkinsonism by adjunctive therapy.
Claims7
A modified peptide of the formula:
- ##STR18## wherein Z is hydrogen, carbobenzyloxy, t-butoxycarbonyl, tosyl, or p-methoxybenzyloxycarbonyl;
- Y is hydrogen or CH.sub.2 CH(CH.sub.3).sub.2 ;
- A is selected from the group consisting of --C(O)OH, --C(O)O lower alkyl, --C(O)NH.sub.2, --C(O)OCH.sub.2 C.sub.6 H.sub.5, --C(O)NH(lower alkyl), --C(O)NH(lower alkyl), --C(O)N(lower alkyl).sub.2, --C(O)NHCH.sub.2 C(O)OH and --C(O)NH(CH.sub.2).sub.n S(lower alkyl) in which n is an integer from two to four, or a pharmaceutically acceptable acid addition or base salt thereof.
Dependencies are inferred from the claim text.