Babesia parasite antigen useful in vaccine and diagnostic reagent
AssigneeUniversity of Illinois Foundation
InventorsMiodrag Ristic, Carlos Arellano
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Abstract
Soluble antigen, specific for Babesia parasites, is isolated from growth media of Babesia-infected erythrocytes in cell culture and characterized, inter alia, by its ability to inhibit the capacity of specific Babesia serum antibodies to neutralize infectivity of Babesia merozoites in vitro. Antigen preparations provide immunologically active components useful for vaccination of animals against infection by Babesia parasites and may be employed in the preparation of diagnostic reagents.
Claims10
A water soluble antigen, specific for Babesia parasites, produced in vitro and characterized by the ability to inhibit the capacity of specific Babesia serum antibodies to neutralize the infectivity of Babesia merozoites in vitro.
A vaccine for use in conferring protection upon an animal against infection by a Babesia parasite, said vaccine comprising in unit dosage form:
- an immunologically effective amount of a water soluble antigen, specific for Babesia parasite, produced in vitro and characterized by the ability to inhibit the capacity of specific Babesia serum antibodies to neutralize the infectivity of Babesia merozoites in vitro;
- and
- an immunologically acceptable diluent, adjuvant or carrier.
A diagnostic reagent for use in detection of a babesiosis disease state, said reagent comprising:
- a water soluble antigen, specific for a Babesia parasite, produced in vitro and characterized by the ability to inhibit the capacity of specific Babesia serum antibodies to neutralize the infectivity of Babesia merozoites in vitro;
- and
- an immunologically acceptable carrier or marker substance.
Dependencies are inferred from the claim text.