Biodegradable porous ceramic delivery system for bone morphogenetic protein
AssigneeThe Regents of the University of California
InventorMarshall R. Urist
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Abstract
Disclosed is a biodegradable porous ceramic delivery system useful for delivery of bone morphogenic protein (BMP) to viable tissue and to induce formation of new bone therein. The delivery composite is substantially pure BMP in combination with a biodegradable porous ceramic (sintered), e.g. beta-tricalcium phosphate, and may be prepared by admixing the BMP with the porous ceramic material. The composition is implanted in viable tissue where the BMP is slowly released and induces formation of new bone.
Claims25
A composition comprising a physiologically acceptable, biodegradable porous ceramic containing bone morphogenic protein (BMP).
A system for delivering bone morphogenic protein (BMP) to viable tissue and inducing formation of new bone therein, comprising:
- a physiologically acceptable, biodegradable porous ceramic containing substantially pure bone morphogenic protein (BMP).
A method for inducing formation of new bone in viable tissue, comprising:
- implanting in said viable tissue a delivery system of a physiologically acceptable, biodegradable porous ceramic containing substantially pure BMP wherein the weight ratio is at least about 1 part BMP to about 100 parts porous ceramic.
A method for preparing a delivery system composite for delivering bone morphogenic protein (BMP) to viable tissue and inducing formation of new bone therein, comprising:
- contacting a physiologically acceptable, biodegradable porous ceramic with a liquid containing substantially pure BMP and removing said liquid therefrom so that an effective amount of BMP is entrapped in the porous ceramic.
A method for preparing a prosthesis for implanting, which comprises:
- providing a bone morphogenic protein (BMP) delivery system of a physiologically acceptable, biodegradable porous ceramic containing substantially pure BMP on at least a portion of the prosthesis.
Dependencies are inferred from the claim text.