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US 4,595,656 AGranted
Coupling agents and products produced therefrom
AssigneeBecton, Dickinson and Company
InventorsStephen D. Allen, Michael Thompson
Life of this patent
Estimating the term…
Abstract
Isocyanate or isothiocyanate substituted lactone or thiolactone is employed for coupling one organic compound to another. For example, such coupling agents can be employed for coupling thyroxine or digoxin to a fluorescent compound for use as a tracer in an assay.
Claims18
A compound having the following structural formula:
- ##STR11## wherein one of R and X is a ligand and the other of R and X is selected from the group consisting of detectable markers, solid supports and therapeutic drugs and when one of R and X is a therapeutic drug, the other of R and X is an antibody,
- Z is selected from the group consisting of --SH and --OH
- Y is selected from the group consisting of ##STR12## when Y is ##STR13## D is selected from the group consisting of --O--, --S--, ##STR14## and when Y is ##STR15## and R' is selected from the group consisting of hydrogen and hydrocarbon radicals.
Dependencies are inferred from the claim text.