Agent facilitating liposome cellular wall transport, a method for the production thereof and its use
OwnerUdo Ehrenfeldinventor
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Abstract
An agent is described in which contains an aldehyde of formula I RCHO (I) in which R is a hydrogen atom, a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms, and preferably an alcohol of formula II R'CH.sub.2 OH (II) in which R' has the meaning indicated above. The agent is used together with charged liposomes. By the administration of the agent, the permeability of the liposomes through tissue cell walls is substantially improved and tagged liposomes accumulate around and in a malignant tumor. A kit for use in diagnosis and therapy is also described.
Claims26
A method of facilitating the transport of liposomes through cellular walls comprising the step of administering to a mammal a liposome cellular wall transport facilitating amount of an aldehyde of formula I
- RCHO (I)
- in which R is a hydrogen atom or a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms or an aldehyde derivative or a chemical compound metabolisable to said aldehyde in combination with an alcohol of formula II
- R'CH.sub.2 OH (II)
- in which R' is a hydrogen atom or a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms and liposomes.
A kit comprising a container of a first reagent and a container of a second reagent, said first reagent comprising a liposome cellular wall transport facilitating amount of an aldehyde of formula I
- RCHO (I)
- in which R is a hydrogen atom or a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms or an aldehyde derivative or a chemical compound metabolisable to said aldehyde in combination with an alcohol of formula II
- R'CH.sub.2 OH (II)
- in which R' is a hydrogen atom or a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms, and said second reagent comprising a pharmaceutically acceptable carrier and a liposome.
Dependencies are inferred from the claim text.