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AssigneeBracco Industria Chimica S.p.A.
InventorsErnst Felder, Maria Zingales, deceased
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Barium sulfate suitable for the preparation of radiographic contrast agents of increased flowability and density is obtained by a high temperature treatment at 700.degree. to 1,200.degree. C. and preferably at 800.degree. to 1,000.degree. C. The barium sulfate so sintered is distinguished by a bulk density of 2.5 to 3 g/ml and its aqueous suspension, containing 200 g of barium sulfate per 100 ml, is distinguished by a viscosity of no more than 1,000 mPas. Radiographic contrast agents containing at least 200 g of sintered barium sulfate per 100 ml are outstandingly suitable for the difficult double contrast visualization of the stomach and gastric mucosa.
A process for the treatment of barium sulfate comprising subjecting precipitated or mineral barium sulfate to a high temperature treatment for a time and temperature sufficient to increase the flowability and bulk density of the barium sulfate to render it suitable for use as a radio-opaque component in radiographic contrast agents.
Barium sulfate having a bulk density of at least 2.5 g/ml and whose suspension in pure water has a viscosity not greater than 1,000 mPas at a concentration of 200 g per 100 ml.
In a radiographic contrast agent composition composed of a radio-opaque effective amount of barium sulfate and conventional additives, the improvement which comprises said barium sulfate having a bulk density of at least 2.5 g/ml and whose suspension in pure water has a viscosity not greater than 1,000 mPas at a concentration of 200 g per 100 ml.
Dependencies are inferred from the claim text.