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US 4,585,652 AGranted
Electrochemical controlled release drug delivery system
AssigneeRegents of the University of Minnesota
InventorsLarry L. Miller, Ronald L. Blankespoor, Baruch Zinger
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Abstract
A method is disclosed for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising ionically binding the chemical to redox sites on a charged polymer and releasing the bound chemical into the medium by neutralizing the charge on the polymer.
Claims19
A method for the controlled delivery of an ionic bioactive chemical into a physiological medium comprising:
- (a) ionically binding said chemical to a polymeric body comprising oppositely-charged redox sites;
- (b) contacting said polymeric body with said physiological medium;
- and
- (c) releasing said bound chemical into said medium as an ionic species by neutralizing the charge on the polymeric body.
1 more element
A system for the controlled release of a bioactive ionic chemical into a physiological medium comprising:
- (a) a working electrode comprising a charged conductive polymer;
- (b) a bioactive ionic chemical ionically bound to said electrode;
- and
- (c) means comprising a power supply of reversible polarity which is capable of charging or discharging said polymer by delivering an anodic or cathodic current thereto.
1 more element
Dependencies are inferred from the claim text.