Antibiotic A80190, pharmaceutical compositions containing same and method of use
AssigneeEli Lilly and Company
InventorsRobert L. Hamill, Raymond C. Yao
Life of this patent
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Abstract
New polyether antibiotic A80190, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A80190 by culture of Actinomodura oligospora NRRL 15877 and synergistic compositions of the A80190 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
Claims53
Antibiotic A80190 which has formula ##STR5## the C.sub.1 -C.sub.7 -alkanoyl and C.sub.1 -C.sub.7 -alkyl esters and C.sub.1 -C.sub.7 -alkyl ethers of A80190 and the salts thereof.
A compound of the formula ##STR6## wherein R is --CONHR.sub.1 and R.sub.1 is C.sub.1 -C.sub.7 -alkyl, C.sub.3 -C.sub.7 -cycloalkyl, an aryl group selected from phenyl, pyridyl or furyl, a specified aryl group which has a C.sub.1 -C.sub.7 -alkyl-, halo, nitro, C.sub.1 -C.sub.7 -alkoxy, a specified-aryloxy or C.sub.1 -C.sub.7 -alkanoyl substituent, or a (specified aryl or substituted aryl)-C.sub.1 -C.sub.7 -alkyl or a (specified aryl or substituted aryl)-C.sub.3 -C.sub.7 -cycloalkyl group;
- or a salt thereof.
Dependencies are inferred from the claim text.