Pharmaceutical compositions containing insulin
AssigneeHadassah Medical Organization
InventorsMiriam Kidron, Ehud Ziv, Hanoch Bar-On, Amiram Eldor
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Abstract
The invention provides a pharmaceutical composition for the oral administration of insulin comprising insulin, a bile acid or alkali metal salt thereof, the bile acid being selected from the group consisting of cholic acid, chenodeoxycholic acid, taurocholic acid, taurochenodeoxycholic acid, glycocholic acid, glycochenocholic acid, 3.beta.-hydroxy-12-ketocholic acid, 12.alpha.-3.beta.-dihydrocholic acid, and ursodesoxycholic acid, and a protease inhibitor, the composition being provided with an enterocoating to assure passage through the stomach and release in the intestine.
Claims4
A pharmaceutical composition for the oral administration of insulin comprising insulin, a bile acid or alkali metal salt thereof which does not cause the damage to the cells of the intestinal wall caused by deoxycholic acid, said bile acid being selected fom the group consisting of sodium cholate cholic acid, chenodeoxycholic acid, taurocholic acid, taurochenodeoxycholic acid, glycocholic acid, glycochenocholic acid, 3.beta.-monohydroxychloric acid, lithocholic acid, 3.alpha.-hydroxy-12-ketocholic acid, 3.beta.-hydroxy-12-ketocholic acid, 12.alpha.-3.beta.-dihydrocholic acid, and ursodesqxycholic acid, and a carefully screened and tested dosage amount of protease inhibitor, said composition being provided with an enterocoating to assure passage through the stomach and release of insulin in the intestine.
Dependencies are inferred from the claim text.