A method for controlling a radial depth of cut of a rotary cutting tool in a numerically controlled machine tool which is provided with a main spindle adapted to be rotated with a tool holder being interchangeably clamped to the forward end thereof and which carries out the machining by a relative movement between said rotary cutting tool and a workpiece, comprising constituting said tool holder so that it is possible to control the radial depth of cut of the tip of said cutting tool held by it through an eccentric mechanism which is adapted to be locked at a fundamental angular position in said tool holder at the time of its release from said main spindle, fitting said tool holder to the forward end of said main spindle which is previously stopped at a predetermined angular position, simultaneously causing the lock of said eccentric mechanism of said tool holder to be released, fastening said tool holder to said main spindle by a clamping mechanism which is passed through the bore formed in said main spindle, making said tool holder able to be rotated in synchronization with said main spindle through a differential mechanism which is adapted to be revolved by a servo-motor, providing a depth of cut controlling shaft through the bore of said clamping shaft so as to be rotatable therein and axially movable therethrough and so as to be engageable with said eccentric mechanism of said tool holder when axially moved forward at the time when said tool holder is at said fundamental angular position, and controlling the position of said tip of said cutting tool, when required, by manipulating said eccentric mechanism through said depth of cut controlling shaft and said differential mechanism by said servo-motor, whereby said control of said eccentric mechanism from said fundamental angular position can be carried out regardless of whether said main spindle is stopped or in motion.