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US 4,568,639 AGranted
Method for the commercial production of helminths antigens
OwnerKenneth K. Lewinventor
Life of this patent
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Abstract
An easily cultured worm is genetically modified such that its surface antigens on its modified form are immunologically identical to the surface antigens of a parasitic worm. Specifically, C. elegans is genetically modified to produce antigens corresponding to the antigens of D. immitis which causes heartworm infection. The antigens derived from the easily cultured worm are used to form a vaccine and/or diagnostic.
Claims9
A method for the production of parasitic helminth antigens which comprises:
- identifying the antigens of D. immitis;
- modifying genetically C. elegans until mutants are formed which mutants are characterized by antigens possessing immunological identity to the antigens of D. immitis;
- isolating at least one of the mutants so modified and
- cultivating at least one of said mutants.
1 more element
A method for the production of parasitic helminth antigens which comprises:
- identifying the antigens of A. canium;
- modifying genetically C. elegans until mutants are formed which mutants are characterized by antigens possessing immunological identity to the antigens of A. canium;
- isolating at least one of the mutants so modified and
- cultivating at least one of said mutants.
1 more element
A method for the production of parasitic helminth antigens which comprises:
- identifying the antigens of D. immitis;
- modifying genetically C. briggsae until mutants are formed which mutants are characterized by antigens possessing immunological identity to the antigens of D. immitis;
- isolating at least one of the mutants so modified and
- cultivating at least one of said mutants.
1 more element
Dependencies are inferred from the claim text.