Back to results
US 4,564,476 AGranted
Aryl fatty acid leukotriene synthesis inhibitors
AssigneeMcNeilab, Inc.
InventorChih Y. Ho
Life of this patent
Estimating the term…
Abstract
Aryl fatty acid compounds of the formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, X, and Y are as defined herein are novel and useful in the treatment of allergic and inflammatory disorders.
Claims11
An aryl fatty acid compound of the following formula (I):
- ##STR9## wherein R.sup.1 and R.sup.2 are independently hydrogen, methyl or fluorine or taken together are ethylene of the formula --CH.sub.2 CH.sub.2 --;
- R.sup.3 is hydrogen, alkyl, alkoxy, alkylthio, halo, alkenyl or hydroxy;
- X is --CH.sub.2 OCH.sub.2 --, --CH.dbd.CH--, or --CH.dbd.CH--CH.sub.2 --O--CH.sub.2 --;
- Y is COOH, alkoxycarbonyl, --CONH.sub.2, --CONHR.sup.4, --CONR.sup.5 R.sup.6, or hydroxyalkyl;
- R.sup.4 is alkyl or hydroxy;
- R.sup.5 is alkyl;
- R.sup.6 is alkyl;
- and,
- when Y is --CO.sub.2 H, the pharmaceutically acceptable base addition salts thereof.
6 more elements
Dependencies are inferred from the claim text.