Inductive collagen based bone repair preparations
AssigneeCollagen Corporation
InventorsRanga Nathan, Saied Seyedin, Karl Piez, Hanne Bentz
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Abstract
A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with an carrier having a percentage of non-fibrillar collagen. The resulting implants are sufficiently hypo-immunogenic to be effective when implanted in xenogeneic hosts.
Claims14
A hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate which comprises an osteoinductively effective amount of a protein osteoinductive factor (OF) derived from bone, which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host in admixture with a carrier which is hypoimmunogenic in a xenogeneic host containing at least 5% by weight of non-fibrillar collagen.
A method of effecting bone repair in vertebrates which comprises implanting into a bone defect a composition hypoimmunogenic in a xenogeneic host which comprises an osteoinductively effective amount of a protein osteoinductive factor (OF) derived from bone, which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, in admixture with a carrier which is hypoimmunogenic in a xenogeneic host containing at least 5% by weight of non-fibrillar collagen.
Dependencies are inferred from the claim text.