Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors

A compound of the formula ##STR313## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is lower alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, aminoalkyl, furyl, furylalkyl, thienyl, thienylalkyl, pyridyl, pyridylalkyl or ##STR314## and R.sub.5 and R.sub.6 are independently selected from hydrogen, lower alkyl, haloalkyl, aryl, alkylaryl, cycloalkyl, cycloalkylalkyl, furyl, furylalkyl, thienyl, thienylalkyl, pyridyl or pyridylalkyl;

• R.sub.2 and R.sub.4 each is independently hydrogen, lower alkyl, arylalkyl, benzhydryl or ##STR315## wherein R.sub.7 is hydrogen, lower alkyl or phenyl, R.sub.8 is hydrogen, lower alkyl, lower alkoxy or phenyl or R.sub.7 and R.sub.8 taken together are --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --CH.dbd.CH--, or ##STR316## n is 0 or 1;
• R.sub.3 is NH.sub.2 (CH.sub.2).sub.m --, ##STR317## R.sub.9 is hydrogen, lower alkyl, aryl or arylalkyl, and m is 0 or an integer of from 1 to 5, and --XOR.sub.4 is an imino or amino acid derivative of the formula ##STR318##