# US 4,557,863 A · Device for collection of proteins in a urinal and method of use > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 4,557,863 A - Document ID: US4557863A - Status: Granted - Kind: A - Application number: 06/600,081 - Filed: 1984-04-13 - Granted: 1985-12-10 - Earliest claimed: 1984-04-13 - Inventors: Denis M. Callewaert; Earl J. Braxton - Web page: https://patentgrep.com/patent/US4557863A ## CPC - A61B 10/007: {for taking urine samples (measuring urological functions A61B5/20; genital receptacles A61F5/451; urinals for bed-ridden persons A61G9/006)} - A61L 28/0038: {Medicaments; Biocides} - Y10S 435/815: by sorption - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ## Abstract The invention relates to a device useful when installed in a urinal for collection of urinary proteins. The adsorbent means includes a conduit for gravity feed passage of urine streams. The conduit has permeable layers in series containing a slow releasing antimicrobial agent and an adsorbent for urinary proteins such that for collection puropses wanted proteins are adsorbed without odor or loss due to bacterial degradation. ## Claims ### Claim 1 A device for installation in a urinal useful for collection of urinary proteins, comprising an open ended columnar conduit for gravity feed passage of urine streams therethrough, and first and second urine stream permeable layers in the conduit, the first and second layers containing respectively (1) a leachable water soluble hydrophilic component comprising an antimicrobial agent and (2) an adsorbent for urinary proteins, the water soluble hydrophilic component including a water soluble antimicrobial that is leached ratably by exposure to intermittent urine streams and a water insoluble hydrophobic component that sublimes ratably to the air thereby gradually exposing the hydrophilic component for slow release, the respective rates of leaching and subliming during the service life being chosen such that the leaching of antimicrobial from the first layer into the second layer is sufficient to provide an inhibitor concentration effectively inhibiting microbial degradation of wanted proteins contained in the adsorbate of the second layer. ### Claim 2 (depends on 1) A device according to claim 1 where the antimicrobial agent specifically inhibits bacterial degradation of urokinase. ### Claim 3 (depends on 1) A device according to claim 1 where the antimicrobial agent comprises a water soluble salt of pyrithione. ### Claim 4 (depends on 1) A device according to claim 1 where the antimicrobial agent comprises sodium pyrithione. ### Claim 5 (depends on 1) A device according to claim 1 where the antimicrobial agent comprises sodium azide. ### Claim 6 (depends on 1) A device according to claim 1 where the first layer contains a hydrophobic component comprising p-dichlorobenzene. ### Claim 7 (depends on 1) A device according to claim 1 where the first layer contains a hydrophobic component comprising naphthalene. ### Claim 8 (depends on 1) A device according to claim 1 where the first layer comprises a homogeneous mixture of sodium pyrithione and p-dichlorobenzene. ### Claim 9 (depends on 1) A device according to claim 1 where the first layer comprises a mixture containing by weight about 5 to about 10% of antimicrobial agent and about 90 to about 95% of a hydrophobic component that sublimes on exposure to air. ### Claim 10 (depends on 9) A device according to claim 9 where the anti-microbial is sodium pyrithione and the hydrophobic component is p-dichlorobenzene. ### Claim 11 (depends on 1) A device according to claim 1 where the adsorbent is an adsorbent of urokinase. ### Claim 12 (depends on 1) A device according to claim 1 where the adsorbent is an ion-exchange resin. ### Claim 13 (depends on 1) A method of collecting urine proteins comprising the steps of installing in a urinal the device according to claim 1 comprising a conduit and first and second urine-stream permeable layers in the conduit and subjecting the permeable layers of the conduit to contact with air and intermittent flow of gravity-fed urine streams under conditions affording leaching of the antimicrobial agent from the first layers into each of the urine streams and adsorption onto the second layer of urinary proteins from each of the resulting leachate streams thereby isolating the resulting adsorbed urinary proteins as a recoverable solid phase adsorbate in the second layer in which layer the antimicrobial leachate inhibits degradation of the adsorbed protein. ### Claim 14 (depends on 13) A method according to claim 13 where the antimicrobial agent specifically inhibits the degradation of urokinase. ### Claim 15 (depends on 13) The method according to claim 13 where the hydrophilic component comprises a water soluble salt of pyrithione. ### Claim 16 (depends on 13) The method according to claim 13 where the hydrophilic component comprises sodium pyrithione. ### Claim 17 (depends on 13) The method according to claim 13 where the hydrophilic component comprises sodium azide. ### Claim 18 (depends on 13) The method according to claim 13 where the first layer contains a hydrophobic component comprising p-dichlorobenzene. ### Claim 19 (depends on 13) The method according to claim 13 where the first layer comprises a homogeneous mixture of sodium pyrithione and p-dichlorobenzene. ### Claim 20 (depends on 13) The method according to claim 13 where the adsorbent is an adsorbent of urokinase. ### Claim 21 (depends on 13) The method according to claim 13 where the adsorbent is an ion-exchange resin.