Process for producing rebeccamycin
AssigneeBristol-Myers Company
InventorsDonald E. Nettleton, Jr., James A. Bush, William T. Bradner, Terrence W. Doyle
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Abstract
A novel antitumor agent designated herein as rebeccamycin is produced by fermentation of Nocardia aerocolonigenes (ATCC 39243). Rebeccamycin and its 5'-N-methyl and 5',2",3",6"-tetraacetate derivatives exhibit activity against experimental animal tumor systems.
Claims2
A process for producing rebeccamycin having the formula ##STR4## which comprises cultivating Nocardia aerocolonigenes ATCC 39243 or a rebeccamycin-producing mutant thereof in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under submerged aerobic conditions until a substantial amount of rebeccamycin is produced by said organism in said culture medium.
Dependencies are inferred from the claim text.