Process for preparing rimantadine
AssigneeE. I. Du Pont de Nemours and Company
InventorJohn J. Liu
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Abstract
A low temperature and pressure process for preparing rimantadine in high yields from 1-adamantyl methyl ketoxime is provided. The process comprises contacting a solution of the ketoxime with hydrogen in the presence of a platinum on carbon catalyst at a low temperature and pressure, e.g., room temperature and a pressure of about 25-115 psia (170-790 KPa) are preferred.
Claims6
In a process for the preparation of rimantadine by the reduction of 1-adamantyl methyl ketoxime, the improvement comprising reducing the ketoxime by contacting a solution of the ketoxime with hydrogen in the presence of a platinum on carbon catalyst at a temperature in the range of about 10.degree.-60.degree. C. and a pressure of about 25 to 215 psia (170-1500 KPa).
In a process for the preparation of rimantadine by the reduction of 1-adamantyl methyl ketoxime, the improvement comprising contacting in a pressurized reaction zone a solution of the ketoxime in acetic acid with hydrogen in the presence of a platinum on carbon catalyst at a temperature in the range of about 10.degree.-30.degree. C. and a pressure in the range of about 25-115 psia (170-790 KPa), and recovering rimantadine from the resulting reaction mixture.
Dependencies are inferred from the claim text.