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US 4,551,435 AGranted
Selective removal of immunospecifically recognizable substances from solution
AssigneeImmunicon Corporation
InventorsPaul A. Liberti, Paul Pollara
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Abstract
A process and apparatus for removing immuno-specifically recognizable substances in the form of immune complexes from a solution. The solution containing preformed immune complexes or immune complexes already present therein is contacted with an adsorbent consisting of non-immunospecific factor such as Clq, rheumatoid factor, Fc receptor and Fc receptor-bearing cells.
Claims20
A method for selectively removing from a solution any soluble or suspended immunospecifically recognizable substance, which method comprises the steps of:
- a. determining the amount of said substance present in said solution;
- b. adding to said solution an immunospecific component capable of reacting specifically with said substance, said component being added in a quantity appropriate to form immune complexes with the amount of said substance determined to be present in said solution, said immune complexes being capable of binding to non-immunospecific factor having an affinity therefor;
- and
- c. contacting said solution with an adsorbent comprising non-immunospecific factor which exhibits an affinity for said immune complexes, whereby said immune complexes become bound to said non-immunospecific factor and said immunospecifically recognizable substance is substantially completely removed from said solution.
1 more element
Dependencies are inferred from the claim text.