Monolithic integrated flow circuit
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsTheodor Kolobow, Yoichiro Ito
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Abstract
A monolithic multi-channel integrated flow circuit comprising a support matrix sheet or plate impressed or embossed with the desired circuitry; the desired circuit elements such as transfer conduit and separation columns are integral with and defined by the support matrix, which conveniently comprises a first deformable support sheet embossed with the circuits elements by thermoforming techniques, and bonded to a support blank or correspondingly embossed second support sheet to complete and define the circuit.
Claims18
A monolithic integrated flow circuit consisting essentially of a deformable matrix plate having a flow circuit formed therein, said deformable matrix plate being of formed plastic or metallic thin-gauge sheets, at least one of said sheets having a pattern formed by embossing thereon, said sheets being bonded together to form said flow pattern, said pattern defining a plurality of locules, each of said locules being joined to an adjacent locule by an integral transfer conduit.
A method for counter-current chromatography comprising separating a first liquid from a second liquid with which said first liquid is mixed by passing a mixture of said first and second liquid through a monolithic integrated flow circuit consisting essentially of a deformable matrix plate having a flow circuit formed therein, said deformable matrix plate being of formed plastic or metallic thin-gauge sheets, at least one of said sheets having a pattern formed by embossing thereon, said sheets being bonded together to form said flow pattern, said pattern defining a plurality of locules, each of said locules being joined to an adjacent locule by an integral transfer conduit and subjecting said mixture to counter-current chromatography in said column.
Dependencies are inferred from the claim text.