Conformationally restricted thymopentin-like compounds
AssigneeOrtho Pharmaceutical Corporation
InventorsGideon Goldstein, George Heavner, Tapan Audhya, Foe-Siong Tjoeng
Life of this patent
Estimating the term…
Abstract
Immunoregulating peptides are disclosed which are cyclic peptides similar to thymopentin. These peptides are useful for their effects on the immune system, especially the treatment of thymic deficiencies.
Claims9
A peptide having the formula:
- ##STR5## or a pharmaceutically-acceptable acid- or base-addition salt thereof, wherein:
- R is H, loweralkyl, formyl or loweralkanoyl;
- W is LYS, PRO, dehydro-PRO, or AIB;
- Z is TYR, TYR-GLY, PHE, or PHE-GLY;
- Z.sup.1 is TYR or PHE;
- R.sup.1 is OH or NR.sup.2 R.sup.3 ;
- and
- R.sup.2 and R.sup.3 are each independently selected from H or loweralkyl.
A peptide having the formula cyclo-(ARG-LYS-ASP-VAL-TYR) or a pharmaceutically-acceptable acid- or base-addition salt thereof.
A peptide having the formula cyclo-(ARG-LYS-ASP-VAL-TYR-GLY) or a pharmaceutically-acceptable acid- or base-addition salt thereof.
A peptide having the formula H-ARG-cyclo-(LYS-ASP)-VAL-TYR-OH or a pharmaceutically-acceptable acid- or base-addition salt thereof.
Dependencies are inferred from the claim text.