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US 4,544,765 AGranted
Chloramphenicol derivatives
AssigneeSyra Company
InventorsPyare Khanna, Evan S. Snyder, Prithipal Singh
Life of this patent
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Abstract
Chloramphenicol derivatives are provided for use in the preparing of antigen conjugates for the production of antibodies specifically for chloramphenicol. Specifically, the aryl amino group is derivatized to introduce a non-oxocarbonyl group which is used for amide formation with an antigen. The conjugate is then injected into a vertebrate for production of antisera which is isolated in conventional ways and find particular use in competitive protein binding assays.
Claims5
A compound of the formula:
- ##STR4## wherein:
- R is an aliphatic linking group of up to 12 atoms other than hydrogen having a chain of from 2 to 8 atoms comprised of carbon, nitrogen, and chalcogen of atomic no. 8 to 16;
- Z is hydrogen, hydroxyl, alkoxyl of from 1 to 6 carbon atoms, a group forming an activated ester capable of amide formation in an aqueous medium, or a poly(amino acid) which is antigenic or an enzyme;
- m is 0 or 1, when Z is a poly(amino acid) and is otherwise 1;
- and
- n is 1 when Z is other than a poly(amino acid) and is otherwise 1 to the molecular weight of Z divided by 1000.
3 more elements
A compound of the formula:
- ##STR5## wherein:
- R is a saturated aliphatic linking group of from 2 to 8 carbon atoms having from 0 to 1 oxo-carbonyl group at the terminus bonded to nitrogen;
- Y.sup.2 is hydrogen, hydroxyl, alkoxyl from 1 to 6 carbon atoms, or a group forming an activated ester capable of amide formation in an aqueous medium;
- m is 1;
- n.sup.2 is 1.
2 more elements
Dependencies are inferred from the claim text.