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US 4,544,759 AGranted
Platinum complexes of antitumor agents
AssigneeAmerican Cyanamid Company
InventorsJoseph J. Hlavka, Panayota Bitha, Yang-i Lin
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Abstract
The compounds are the class of substituted hydrazine carboximidamides which are useful for inducing the regression and/or palliation of leukemia and related cancers in mammals when administered in amounts of from about one mg. to about 1.2 gm. per square meter of body surface area per day.
Claims16
A compound of the formula:
- ##STR3## wherein R.sub.1 is amino, benzyl, cyano, --CONH.sub.2 or --N.dbd.C(CH.sub.3).sub.2 ;
- R.sub.2 is hydrogen or alkyl(C.sub.1 -C.sub.3);
- R.sub.3 is amino, hydrazino, dialkylamino(C.sub.1 -C.sub.3), nitroamino, alkyl(C.sub.1 -C.sub.3), phenyl, p-chlorophenyl, p-methoxyphenyl, phenylamino, benzylamino, alkylamino(C.sub.1 -C.sub.3), alkylthio(C.sub.1 -C.sub.3), diphenylamino or --NH(CH.sub.2).sub.n N(CH.sub.3).sub.2 where n is an integer 2-4;
- R.sub.4 is hydrogen or benzyl;
- and L and L' are the same and are anions selected from the group consisting of halide, nitrate, sulfate and (C.sub.2 -C.sub.6)alkanoate or L and L' taken together is a dibasic anion selected from the group consisting of oxalate, malonate, methylamalonate, ethylmalonate, succinate, tartronate, 1,1-cyclopropane dicarboxylate and 1,1-cyclobutane dicarboxylate.
2 more elements
Dependencies are inferred from the claim text.