3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels
AssigneeEli Lilly and Company
InventorsJames R. Beck, Robert P. Gajewski, Ronald E. Hackler
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Abstract
3-Phenyl (or meta or para-substituted phenyl)-4-permissibly substituted-5-isothiazolecarboxylic acids, salts, esters and simple amides, used to lower uric acid levels in mammals.
Claims8
A compound of the formula ##STR11## wherein X is NH.sub.2, OH, hal, H or NHalk;
- and R is OH or OM;
- wherein hal is Cl, Br, I or F;
- alk is (C.sub.1 -C.sub.3) alkyl and M is a non-toxic cation.
A compound of the group 3-(3-fluoro-4-methoxyphenyl)-4-amino-5-isothiazolecarboxylic acid, 3-(4-isopropoxyphenyl)-4-amino-5-isothiazolecarboxylic acid, 3-(4-anisyl)-4-chloro-5-isothiazolecarboxylic acid and 3-(3-chlorophenyl)-4-chloro-5-isothiazolecarboxylic acid.
A compound of the formula ##STR12## wherein X is NH.sub.2, H, OH, hal or Nalk;
- and R is NH.sub.2, NHalk or N(alk).sub.2, wherein hal is F, Cl, Br or I and alk is (C.sub.1 -C.sub.3) alkyl.
Dependencies are inferred from the claim text.