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AssigneeThe Procter & Gamble Company
InventorsThomas R. LaHann, John M. Janusz, Brian L. Buckwalter
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Alkadienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched diene having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkadienamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkadienamides are N-vanillyl-alkadienamides. Methods of treatment, comprising administering a safe and effective amount of these alkadienamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.
Alkadienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula:
The alkadienamide compound N-vanillyl-(Z,Z)-11,14-eicosadienamide, and pharmaceutically-acceptable salts thereof.
A composition for producing analgesia in humans or lower animals, comprising:
A method for producing analgesia in humans or lower animals, which comprises administering to said human or lower animal a safe and effective amount of an alkadienamide compound or pharmaceutically-acceptable salt thereof, or mixtures thereof, of the formula:
Dependencies are inferred from the claim text.