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AssigneeThe Procter & Gamble Company
InventorsJohn M. Janusz, Brian L. Buckwalter, Thomas R. LaHann
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Methylenealkanamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched methylene substituted alkane having from 11 to 23 carbon atoms; R.sub.1 is H, OH, or OCH.sub.3 ; R.sub.2 is OH or a short-chain ester; and wherein at least one of R.sub.1 and R.sub.2 is OH or OCH.sub.3. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: a methylenealkanamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these methylenealkanamides are N-vanillyl-methylenealkanamides. Methods of treatment, comprising administering a safe and effective amount of these methylenealkanamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral and topical administration.
Methylenealkanamide compounds, and pharmaceutically-acceptable salts thereof, of the formula:
A composition for producing analgesia in humans or lower animals, comprising:
A method for producing analgesia in humans or lower animals, which comprises administering to said human or lower animal a safe and effective amount of a methylenealkanamide compound or pharmaceutically-acceptable salt thereof, or mixtures thereof, of the formula:
Dependencies are inferred from the claim text.