1'-Substituted-spiro[oxazolidine-5-3'-indoline]-2,2', 4-trione derivatives
AssigneeImperial Chemical Industries PLC
InventorsDavid R. Brittain, Robin Wood
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Abstract
The invention provides novel spiro[oxazolidine-5,3'-indoline]-2,2',4-triones of formula I bearing substituted benzyl or cinnamyl on the indoline nitrogen, together with salts and non-toxic, biodegradable precursors thereof. The compounds are potent inhibitors of the enzyme aldose reductase and are useful in treating or preventing certain diabetic complications. The invention also provides pharmaceutical compositions containing, and processes for the manufacture of, the compounds of formula I and their salts and derivatives.
Claims5
A 1'-substituted-spiro[oxazolidine-5,3'-indoline]-2,2',4-trione of the formula:
- ##STR9## wherein Rb is methyl;
- Rc is hydrogen or chloro;
- and benzene ring B is selected from 4-bromophenyl, 3,4-dibromophenyl, 3,4-dichlorophenyl, 3-bromo-4-chlorophenyl, 4-bromo-3-chlorophenyl, 4-bromo-2-fluorophenyl and 2-fluoro-4-iodophenyl.
Dependencies are inferred from the claim text.