Pharmaceutical composition and method of treating psoriasis
OwnerDonncha O'Sullivaninventor
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Abstract
A method of treating psoriasis and similar or related ailments comprises applying to an affected skin area a therapeutically effective amount of at least one skin-compatible zwitterionic aminosulfonic acid (ZASA) of the formula RNR'SO.sub.3 H wherein R is a straight or branched chain aliphatic radical, or RN is a substituted or unsubstituted nitrogen-containing heterocycle which may have one additional hetero atom; and R' is C.sub.2-4 straight or branched chain alkylene radical. A pharmaceutical composition is also provided, and comprises at least one ZASA of the above formula together with a pharmaceutically acceptable topical carrier or base.
Claims18
A method of treating psoriasis which comprises applying to an affected area of skin a therapeutically effective amount of at least one skin-compatible zwitterionic aminosulfonic acid (one ZASA) having the formula
- RNR'SO.sub.3 H
- wherein R represents tris-(hydroxymethyl)-methyl or the combination RN represents a radical selected from the group consisting of N-piperazinyl, N-morpholinyl, and N-[N'-(2-hydroxyethyl)]-piperazinyl;
- and R' is a C.sub.2-4 straight or branched chain alkylene radical.
A method of treating psoriasis which comprises applying to an affected area of skin a therapeutically effective amount of at least one skin-compatible zwitterionic aminosulfonic acid (one ZASA) having the formula:
- RNR'SO.sub.3 H
- wherein either R is a C.sub.1-6 straight or branched chain aliphatic radical or the combination RN is a substituted or unsubstituted nitrogen-containing heterocyclic radical which may have one hetero-atom additional to the nitrogen atom that links said radical to R';
- and R' is a C.sub.2-4 straight or branched chain alkylene radical, said ZASA being non-toxic, non-carcinogenic and non-irritating.
A pharmaceutical composition for application to the human skin in the treatment of psoriasis comprising a therapeutically effective amount of at least one skin-compatible zwitterionic aminosulfonic acid (one ZASA) having the formula:
- RNR'SO.sub.3 H
- wherein R represents tris-(hydroxymethyl)-methyl or the combination RN represents a radical selected from the group consisting of N-piperazinyl, N-morpholinyl, and N-[N'-2-(2-hydroxyethyl)]-piperazinyl;
- R' represents a C.sub.2-4 straight or branched chain alkeyne radical, and a pharmaceutically acceptable topical carrier or base, said pharmaceutical composition being in the form of a cream, solid, ointment or lotion.
A pharmaceutical composition for application to the human skin in the treatment of psoriasis comprising a therapeutically effective amount of at least one skin-compatible zwitterionic aminosulfonic acid (one ZASA) having the formula:
- RNR'SO.sub.3 H
- wherein either R is a C.sub.1-6 straight or branched chain aliphatic radical or the combination RN is a substituted or unsubstituted nitrogen-containing heterocyclic radical which may have one hetero-atom additional to the nitrogen atom that links said radical to R';
- and R' is a C.sub.2-4 straight or branched chain alkylene radical, said ZASA being non-toxic, non-carcinogenic, and non-irritating, and a pharmaceutically acceptable topical carrier or base, said pharmaceutical composition being in the form of a cream, solid, ointment or lotion.
Dependencies are inferred from the claim text.