Antiinflammatory, analgesic, and antirheumatic 4-hydroxy-2-methyl-n-(2-pyridyl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2- thiazine-3-carboxamide 1,1-dioxide, corresponding compositions, and 3-carboxylic acid lower alkyl ester intermediates
AssigneeHoffmann-La Roche Inc.
InventorsRudolf Pfister, Paul Zeller, Dieter Binder, Otto Hromatka
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Abstract
4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3-e ]-1,2-thiazine 1,1-dioxide of the formula ##STR1## and its pharmaceutically acceptable salts which possess valuable pharmacodynamic properties are described. More particularly, the compound and its salts display antiinflammatory, analgesic and antirheumatic activities and they are readily accessible by reacting a corresponding alkyl ester with 2-aminopyridine and, if desired, subsequent salt formation.
Claims5
4-Hydr oxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2- thiazine 1,1-dioxide of the formula ##STR8## or a pharmaceutically acceptable salt thereof.
A compound of the formula ##STR9## wherein R is lower alkyl.
An antiinflammatory composition consisting of an antiinflammatorily effective amount of 4-hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3- e]-1,2-thiazine 1,1-dioxide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable inert carrier.
An analgesic composition consisting of an analgesically effective amount of 4-hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3- e]-1,2-thiazine 1,1-dioxide or a pharmaceutically acceptable salt thereof and an inert carrier.
An antirheumatic composition consisting of an antirheumatically effective amount of 4-hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3- e]-1,2-thiazine 1,1-dioxide or a pharmaceutically acceptable salt thereof and an inert carrier.
Dependencies are inferred from the claim text.