Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof

A compound according to the formula:

• ##STR7## wherein R=lower alkyl, cycloalkyl, cycloalkyl(lower)alkyl, benzyl, or benzyl substituted by halogen, loweralkyl, loweralkoxy, or lower alkyl substituted by hydroxy, lower alkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl and sulfamoyl;
• X,X.sub.1 =hydrogen and halogen;
• R.sub.1 =hydrogen, loweralkyl, unsaturated loweralkyl, loweralkoxyloweralkyl, or collectively with R.sub.2 is an alkylene chain forming an azetidine, pyrrolidine, piperidine, or hexahydroazepine ring, or collectively with R.sub.3 is a bond or an alkylene chain forming an azetidine, pyrrolidine, piperidine or a hexahydroazepine ring, or collectively with R.sub.5 may produce a piperazine or a hexahydro-1,4-diazepine ring system;
• R.sub.2 =hydrogen, loweralkyl or collectively with R.sub.3 is a bond or an alkylene chain to form a saturated carbocyclic ring of from 4 to 8 ring carbon atoms.
• R.sub.3,R.sub.4 =hydrogen, loweralkyl or collectively is an alkylene chain forming a saturated carbocyclic ring of from 4 to 6 ring carbon atoms;
• R.sub.5,R.sub.6 =unsaturated loweralkyl, C.sub.1 -C.sub.12 straight or branched chain alkyl, C.sub.3 -C.sub.6 cycloalkyl, cycloalkyl(lower)alkyl, or when taken together form a saturated heterocyclic ring of from 4 to 8 ring members which may be substituted by one or more methyl groups or optionally contains a --O--, or ##STR8## linkage wherein p is the integer 0, 1 or 2;
• R.sub.6 =loweralkyl substituted by phenyl which may be substituted by up to 3 substituents selected from hydroxy or methoxy groups;
• n=0, 1, 2;
• and the pharmaceutically acceptable salts thereof;
• with the proviso that:
• (a) when any of R.sub.1, R.sub.5 or R.sub.6 is unsaturated loweralkyl, the unsaturation cannot be alpha to the nitrogen atom.