Anti immune complex antibody for determining SLE, rheumatoid arthritis or tetanus
AssigneeFujizoki Pharmaceutical Co., Ltd.
InventorsKazunori Soma, Yasushi Kasahara
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Abstract
An antibody is obtained by using as an antigen a complex of an antigen and the F(ab').sub.2 fragment of the human antibody of this antigen or an aggregate of the F(ab').sub.2 fragment of human immunoglobulin. This antibody reacts with an immune complex in a blood serum of a patient of systemic lupus erythematosus and with an immune complex in a blood serum of a patient of rheumatoid arthritis, and it does not react with an aggregated IgG. The amount of immune complex in a blood serum is easily and exactly determined by using this antibody.
Claims22
An anti-immune complex antibody, which is a glycoprotein having a molecular weight of from 150,000 to 180,000, as determined by gel filtration, reacts with an immune complex in a blood serum of a human patient having systemic lupus erythematosus, rheumatoid arthritis or tetanus, and which does not react with aggregated IgG.
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