Liposomes containing modified cholesterol for organ targeting
AssigneeTrustees of the University of Massachusetts
InventorsPatrick J. Ryan, Michael A. Davis, Donald L. Melchior
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Abstract
Phospholipid liposomes are provided having an outer layer including a cholesterol derivative such as a cholesterol ester and an aqueous medium confined by the layer which includes a tracer agent, a cytoxic agent or a therapeutic agent. The liposomes are adapted for specific organ targeting.
Claims12
In a liposome formed by the incapsulation of an active agent by at least one lipid containing bilayer, the improvement comprising a ligand modified cholesterol compound in the lipid of said bilayer, said ligand being positioned at the 3 carbon position of said cholesterol, said ligand modified cholesterol compound rendering the liposome more specific for accumulation at a pre-selected organ in vivo.
Dependencies are inferred from the claim text.