Aryl coupling process
AssigneeEthyl Corporation
InventorRobert I. Davidson
Life of this patent
Estimating the term…
Abstract
An arylamine is coupled with an aromatic compound in the presence of water, an inorganic nitrite, and an alkanoic acid containing 5-7 carbons. In a preferred embodiment of the invention, 2-(4-amino-3-fluorobenzene)propionitrile is coupled with benzene in the presence of water, sodium nitrite, and hexanoic acid to form a flurbiprofen intermediate.
Claims14
A process which comprises coupling (A) an aminohalobenzene bearing a substituent corresponding to the formula --CHYR" wherein R" is hydrogen or an alkyl group of 1-6 carbons, Y is --CN or --COOR.sub.1, and R.sub.1 is an alkyl group of 1-6 carbons with (B) a benzene compound selected from benzene and hydroxy, halo, nitro, alkyl, alkoxy, alkoxycarbonyl, aryloxycarbonyl, phenyl, cyano, and cycloalkyl substituted benzenes wherein the substituents contain not more than about 10 carbons in the presence of water, an inorganic nitrite, and an alkanoic acid containing 5-7 carbons.
A process which comprises coupling 2-(4-amino-3-fluorobenzene)propionitrile with benzene in the presence of water, sodium nitrite, and an alkanoic acid containing 5-7 carbons.
A process which comprises coupling 2-(4-amino-3-fluorobenzene)propionitrile with benzene in the presence of water, sodium nitrite, and hexanoic acid.
Dependencies are inferred from the claim text.