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US 4,544,501 AGranted
Bis(2,2-dimethyl-1-aziridinyl)phosphinic amides for use in the treatment of tumors
AssigneeThe Research Foundation of State University of New York
InventorsThomas J. Bardos, Michael E. Perlman, Joan E. MacDiarmid
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Abstract
Novel bis(2,2-dimethyl-1-aziridinyl)phosphinic amide antineoplastic agents are disclosed of the formula: ##STR1## wherein R and R' are each, independently, hydrogen, alkyl, substituted alkyl, phenyl and substituted phenyl and, Z is oxygen or sulfur.
Claims6
A compound having the formula:
- ##STR9## wherein R and R' are independently hydrogen, or substituted alkyl of up to about 10 carbon atoms, wherein each substituent is selected from the group consisting of amine and alkoxy, and Z is oxygen provided at least one of R or R' is substituted alkyl.
The compound of the structure ##STR12##
The compound of the structure ##STR13##
Dependencies are inferred from the claim text.