US 4,544,371 AGranted

Implantable metered dose drug delivery system

AssigneeAmerican Hospital Supply Corporation

InventorsRay H. Dormandy, Jr., Frederick L. Coe

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Abstract

An implantable metered dose drug delivery system is disclosed which comprises implantable components including an injection site, reservoir, metering valve and delivery catheter, all of which are interconnected through suitable tubing. The metering valve has a domed body constructed of a resilient elastomeric material with a fluid-flow passageway extending therethrough and opening into a chamber within the domed body. A valve is positioned within an outlet leading from the chamber, which valve is opened by exerting an external pressure on the domed body to first collapse and occlude the fluid-flow passageway and then open the valve to permit medication within the chamber to flow through the outlet. Upon release of the external pressure, the fluid-flow passageway opens and reduced pressure in the chamber draws additional fluid through the passageway to fill the chamber.

Claims23

Dependent claims

An implantable metered dose drug delivery system comprising:

a puncturable and resealable injection site for providing an access to the system;
a reservoir in fluid-flow communication with the injection site;
a metering valve means in fluid-flow communication with the reservoir for measuring and storing a dosage amount of a drug to be administered and delivering the drug in dosage amounts upon external actuation, the metering valve means comprising a base, a resilient elastomeric solid body attached to the base, which resilient elastomeric solid body defines a chamber and a fluid passageway extending along its entire length within the resilient elastomeric solid body and which fluid passageway is in fluid communication with the chamber and deformable upon application of an external pressure applied to the resilient elastomeric solid body, an inlet conduit attached to the resilient elastomeric solid body in fluid-flow communication with the fluid passageway, an outlet conduit attached to the resilient elastomeric solid body in fluid-flow communication with the chamber, and a one-way valve means provided within the outlet conduit for opening and providing fluid flow from the chamber through the outlet conduit upon an external pressure being applied against the resilient elastomeric solid body, which external pressure collapses the fluid passageway occluding the fluid passageway to fluid flow and concomitantly collapses the chamber expelling any drug in the chamber from the chamber;
and
a delivery catheter fluid-flow communication with the metering valve means for delivering the drug dosage to the body.

2 more elements

Dependencies are inferred from the claim text.