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US 4,543,415 AGranted
Process for preparing tricyclic indoles
AssigneeMerck & Co., Inc.
InventorGerald S. Ponticello
Life of this patent
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Abstract
An improved process for preparing 5-keto-1,3,4,5-tetrahydrobenz[c,d]indole and 6(1H)-oxo-3,4,5,6-tetrahydrocyclohept[c,d]indole is disclosed.
Claims4
A process for preparing a compound of the formula:
- ##STR10## which comprises the steps of (1) treating a compound of the formula:
- ##STR11## wherein R is C.sub.1 -C.sub.3 alkyl, with a metalhydride, strong base in dimethylformamide or dimethylsulfoxide solvent to obtain a product of the formula ##STR12## and (2) hydrolyzing II with a suitable alkali metal base or mineral acid and decarboxylating the hydrolysis product by heating to obtain the formula I' compound.
Dependencies are inferred from the claim text.