.+-.2-[Phenethyl]-5-[(3,4-methylenedioxy)-.alpha.-hydroxybenzyl]py rrolidine antihypertensives and use thereas
OwnerJoseph M. Muchowski, Robert Greenhouse +3inventors
InventorsJoseph M. Muchowski, Robert Greenhouse, Jack Ackrell, Tsung-Tee Li, Jurg R. Pfister
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Abstract
A compound of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof are potent antihypertensive agents and are therefore useful as cardiovascular system regulators.
Claims9
A compound of the formula ##STR17## namely, .+-.2-[phenethyl]-5-[(3,4-methylenedioxy)-.alpha.-hydroxybenzyl]pyrrolidin e and the pharmaceutically acceptable acid addition salts thereof.
A compound of the formula ##STR18## and its enantiomer, namely, (.+-.), (+), and (-) cis erythro 2-[phenethyl]-5-[(3,4-methylenedioxy)-.alpha.-hydroxybenzyl]pyrrolidine and the pharmaceutically acceptable acid addition salts thereof.
A compound of the formula ##STR19## and its enantiomer, namely, (.+-.), (+), and (-) cis threo 2-[phenethyl]-5-[(3,4-methylenedioxy)-.alpha.-hydroxybenzyl]pyrrolidine and the pharmaceutically acceptable acid addition salts thereof.
A compound of the formula ##STR20## and its enantiomer, namely, (.+-.), (+), and (-)trans erythro 2-[phenethyl]-5-[(3,4-methylenedioxy)-.alpha.-hydroxybenzyl]pyrrolidine and the pharmaceutically acceptable acid addition salts thereof.
A compound of the formula ##STR21## and its enantiomer, namely, (.+-.), (+), and (-)trans threo 2-[phenethyl]-5-[(3,4-methylenedioxy)-.alpha.-hydroxybenzyl]pyrrolidine and the pharmaceutically acceptable acid addition salts thereof.
A pharmaceutical composition which comprises a therapeutically effective amount of a compound of formula ##STR22## and the pharmaceutically acceptable acid addition salts in admixture with a pharmaceutically acceptable excipient.
A method for regulating hypertension in mammals which method comprises administering to a subject in need of such treatment a therapeutically effective amount of the compound of the formula ##STR23## and the pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.